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Principal Scientist/Associate Director, Preclinical Pharmacology

Watertown, MA

Principal Scientist/ Associate Director, Preclinical Pharmacology 

Triveni Bio is breaking new ground on the identification of novel disease targets – working at the convergence of human genetics, best-in-class antibody design, and precision medicine.  We are pioneering a Mendelian genetics-informed precision medicine approach to develop functional antibodies for the treatment of immunological and inflammatory (I&I) disorders. Our lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7) and directly impacts skin barrier function, inflammation, and itch – providing a meaningful and much needed potential treatment option for patients with atopic dermatitis and other barrier disorders.

Role summary

We are seeking an experienced and motivated individual to lead and execute in vivo pharmacology strategies and activities. This position will report to the VP of Biology. 

Key Responsibilities

  • Drive in vivo pharmacological research strategy to guide novel antibody therapeutics in inflammation and immune disorders
  • Lead and execute pharmacology research activities, leveraging CROs by coordinating and managing external in vivo studies
  • Analyze and interpret data from experiments and studies to generate high-quality data to support program timelines and goals
  • Identify or develop novel in vivo rodent disease models for proof-of mechanism and proof-of concept studies 
  • Participate in cross-functional project teams as an in vivo biology and pharmacology subject matter expert 
  • Contribute to strategies on translational molecular understanding of human diseases and biomarker identification

Qualifications

  • PhD and at least 8 years of relevant experience in immunology and antibody drug development, preferably from pharmaceutical or biotechnology sector
  • Extensive expertise in preclinical models commonly used in atopic dermatitis, asthma, and other inflammatory diseases 
  • Proven track record of successfully managing in vivo studies through domestic and international CROs
  • Excellent verbal and written communication and interpersonal skills to work across research projects 
  • Organized and experienced with documentation of experimental plans, budget, and technical reports 
  • Desire and capacity to thrive in a dynamic and fast-paced research setting

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